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Center for Thrombosis and Hemostasis (CTH)

Professorship for Clinical Trials

Stavros V. Konstantinides, MD, PhD, FESC
Medical Director of the CTH

Module C of the CTH initiates, designs, coordinates and conducts multicenter clinical trials on thrombotic disorders and antithrombotic treatment. Our research mainly focuses on advancing and optimizing the management of venous thromboembolism (VTE). In ongoing prospective cohort studies and interventional trials, we are developing and evaluating novel strategies for risk stratification of patients with acute pulmonary embolism (PE). Further studies of our Module concentrate on the feasibility and safety of home treatment of selected low-risk patients with PE, and on the risk of developing Chronic Thromboembolic Pulmonary Hypertension (CTEPH) after acute VTE.

Beyond individual research projects, the vision of our Module and of the CTH is to play a leading role in networking national and European research groups and centers of excellence in the field of PE. With the support of experts from 15 European countries and from North America, we are currently in the process of constructing the European Pulmonary Embolism Network (EPENet).

A detailed overview of all ongoing projects as well as staff of "Clinical Trials" is available on our website www.unimedizin-mainz.de/cth-clinical-trials.

Research Interests

  • Development and evaluation of multimarker strategies and combined scores for risk stratification of intermediate-risk PE
  • Selection of low-risk patients with acute PE for early discharge and home treatment
  • Investigation of cardiovascular risk factors common to arterial and venous thrombosis
  • Long-term follow-up after acute VTE to assess the incidence and pathogenesis of CTEPH

Partners of Collaboration

  • Partners of the University Medical Center Mainz:  Prof. H. Binder, IMBEI; Prof. C. Espinola-Klein, Department of Medicine II, Sec. Angiology; Prof. T. Münzel, Department of Medicine II; Prof. M. Seibert-Grafe, IZKS Mainz
  • European partners: Prof. C. Becattini, Perugia, IT; Prof. C. Binder, Vienna, AT; Prof. B. Brenner, Haifa, IL; Prof. P. Corris, Newcastle, UK; Prof. A. Geibel, Freiburg, DE; Prof. D. Jimenez, Madrid, ES; Dr. M. Kozak, Ljubljana, SLO; Prof. N. Kucher, Bern, CH; Prof. I. Lang, Vienna, AT; Prof. N. Meneveau, Besançon, FR; Prof. G. Meyer, Paris, FR; Prof. M. Monreal, Barcelona, ES; Prof. P. Pruszczyk, Warsaw, PL; Prof. M. Samarzija, Zagreb, HR; Prof. B. Stefanovic, Belgrade, SRB; Prof. A. Torbicki, Otwock, PL; Prof. T. Thum, Hannover, DE; Prof. D. Tziakas, Alexandroupolis, GR; Prof. F. Verschuren, Leuven, BE
  • Prof. S.Z. Goldhaber, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, US, and the North American Thrombosis Forum (NATF)

Research Funding

  • Bundesministerium für Bildung und Forschung – German Federal Ministry for Education and Research (Clinical Trial Funding Program, 2008-2013)
  • Deutsche Gesellschaft für Kardiologie, Herz- und Kreislaufforschung – German Cardiac Society
  • Pharmaceutical industry (co-funding of investigator initiated clinical trials of the Module)

The team of the Professorship for Clinical Trials you will find in building 403, 1st floor.

Team - Module Clinical Trials

Konstantinides, MD
Professor Stavros Konstantinides, MD

Position: Medical Director CTH / Head of the professorship "Clinical Trials" (module C) / Deputy Speaker of the CTH / Medical Director of CTH Outpatient Clinic
Qualifications: Specialist in Internal Medicine/Cardiology


Lankeit, MD
Mareike Lankeit, MD

Position: Junior group leader


Project management

Kristin Geilert

Position: Project coordination "Clinical Trials"

Phone 06131/17-8382
Fax 06131/17-8461

Kurt Quitzau

Position: Study coordinator

Phone 06131/17-8252
Fax 06131/17-8461

PhD Heydenreich
Nadine Heydenreich , PhD

Position: Study coordinator

Phone 06131/17-8376

Wärntges, MD
Simone Wärntges, MD

Position: Research doctor

Phone 06131/17-8251
Fax 06131/17-8461


Käberich, MD
Anja Käberich, MD

Position: Research physician


Klok, MD, PhD
Frederikus (Erik) Klok, MD, PhD

Position: Candidate of the Virchow-Fellowship-Program / Research doctor

Phone 06131/17-8380
Fax 06131/17-8461
Further Information

Kathrin Rost

Position: Medical technical assistance

Phone 06131/17-8385
Fax 06131/17-8461

Schmidt, MD
Kai-Helge Schmidt, MD

Position: Specialist in Internal Medicine
Qualifications: Assistant doctor


cand. med. Terporten
Johannes Terporten, cand. med.

Position: PhD student


Valerie Seeber

Position: Statistician

Phone 06131/17-8384
Fax 06131/17-8461

Study nurses

Beate Berghausen

Position: Study Nurse

Phone 06131/17-8386
Fax 06131/17-47 1622

Brunhilde Fischer

Position: Study Nurse

Phone 06131/17-8386
Fax 06131/17-8461


  • Konstantinides S, Lankeit M. Pulmonary embolism holinw 2012. Recent and expected trials. Hamostaseologie 2013. Feb; 33(1):43-50. doi: 10.5482/HAMO-12-12-0024.

  • Lankeit M, Gómez V, Wagner C, Aujesky D, Recio M, Briongos S, Moores L, Yusen R, Konstantinides S, Jiménez D on behalf of the IRYCIS Pulmonary Embolism Study Group. A strategy combining imaging and laboratory biomarkers in comparison to a simplified clinical score for risk stratification of patients with acute pulmonary embolism. Chest 2012;141:916-922.

  • Lankeit M, Jiménez D, Kostrubiec M, Dellas C, Hasenfuß G, Pruszczyk P, Konstantinides S. Predictive value of the highly sensitive troponin T assay and the simplified Pulmonary Embolism Severity Index in hemodynamically stable patients with acute pulmonary embolism: a prospective validation study. Circulation 2011;124:2716-2724.

  • Konstantinides S, for the PEITHO Steering Committee. Single-bolus tenecteplase plus heparin compared with heparin alone for normotensive patients with acute pulmonary embolism who have evidence of right ventricular dysfunction and myocardial injury: rationale and design of the Pulmonary Embolism Thrombolysis (PEITHO) trial. Am Heart J 2012;163:33-38.e1.

  • Dellas C, Lankeit M, Reiner C, Schäfer K, Hasenfuss G, Konstantinides S. BMI-independent inverse relationship of plasma leptin levels with outcome in patients with acute pulmonary embolism. Int J Obes (Lond) 2013 Feb; 37(2):204-10

  • Vedovati MC, Becattini C, Agnelli G, Kamphuisen PW, Masotti L, Pruszczyk P, Casazza F, Salvi A, Grifoni S, Carugati A, Konstantinides S, Schreuder M, Golebiowski M, Duranti M. Multidetector computed tomography for acute pulmonary embolism: embolic burden and clinical outcome. Chest 2012 May; 142(6):1417-24

  • Konstantinides S, Goldhaber SZ. Pulmonary embolism: risk assessment and management. Eur Heart J 2012; 33(24):3014-22.

The new guidelines of the ESC (2.5 MB) for diagnosis and therapy of acute pulmonary embolism (Chair of the Task Force: Stavros Konstantinides) were presented on the ESC in Barcelona.
Summary in German. (199 KB)