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Center for Thrombosis and Hemostasis (CTH)
 

Professorship for Clinical Trials

Stavros V. Konstantinides, MD, PhD, FESC
Deputy Scientific Director of the CTH


Module C of the CTH initiates, designs, coordinates and conducts multicenter clinical trials on thrombotic disorders and antithrombotic treatment. Our research mainly focuses on advancing and optimizing the management of venous thromboembolism (VTE). In ongoing prospective cohort studies and interventional trials, we are developing and evaluating novel strategies for risk stratification of patients with acute pulmonary embolism (PE). Further studies of our Module concentrate on the feasibility and safety of home treatment of selected low-risk patients with PE, and on the risk of developing Chronic Thromboembolic Pulmonary Hypertension (CTEPH) after acute VTE.

Beyond individual research projects, the vision of our Module and of the CTH is to play a leading role in networking national and European research groups and centers of excellence in the field of PE. With the support of experts from 15 European countries and from North America, we are currently in the process of constructing the European Pulmonary Embolism Network (EPENet).

A detailed overview of all ongoing projects as well as staff of "Clinical Trials" is available on our website www.unimedizin-mainz.de/cth-clinical-trials.

Research Interests

  • Development and evaluation of multimarker strategies and combined scores for risk stratification of intermediate-risk PE
  • Selection of low-risk patients with acute PE for early discharge and home treatment
  • Investigation of cardiovascular risk factors common to arterial and venous thrombosis
  • Long-term follow-up after acute VTE to assess the incidence and pathogenesis of CTEPH

Partners of Collaboration

  • Partners of the University Medical Center Mainz:  Prof. H. Binder, IMBEI; Prof. C. Espinola-Klein, Department of Medicine II, Sec. Angiology; Prof. T. Münzel, Department of Medicine II; Prof. M. Seibert-Grafe, IZKS Mainz
  • European partners: Prof. C. Becattini, Perugia, IT; Prof. C. Binder, Vienna, AT; Prof. B. Brenner, Haifa, IL; Prof. P. Corris, Newcastle, UK; Prof. A. Geibel, Freiburg, DE; Prof. D. Jimenez, Madrid, ES; Dr. M. Kozak, Ljubljana, SLO; Prof. N. Kucher, Bern, CH; Prof. I. Lang, Vienna, AT; Prof. N. Meneveau, Besançon, FR; Prof. G. Meyer, Paris, FR; Prof. M. Monreal, Barcelona, ES; Prof. P. Pruszczyk, Warsaw, PL; Prof. M. Samarzija, Zagreb, HR; Prof. B. Stefanovic, Belgrade, SRB; Prof. A. Torbicki, Otwock, PL; Prof. T. Thum, Hannover, DE; Prof. D. Tziakas, Alexandroupolis, GR; Prof. F. Verschuren, Leuven, BE
  • Prof. S.Z. Goldhaber, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, US, and the North American Thrombosis Forum (NATF)

Research Funding

  • Bundesministerium für Bildung und Forschung – German Federal Ministry for Education and Research (Clinical Trial Funding Program, 2008-2013)
  • Deutsche Gesellschaft für Kardiologie, Herz- und Kreislaufforschung – German Cardiac Society
  • Pharmaceutical industry (co-funding of investigator initiated clinical trials of the Module)

The team of the Professorship for Clinical Trials you will find in building 403, 1st floor.

Team - Module Clinical Trials

Konstantinides, MD
Professor Stavros Konstantinides, MD

Position: Head of the professorship "Clinical Trials" (module C) / Deputy Scientific Director of the CTH / Medical Director of CTH Outpatient Clinic
Qualifications: Specialist in Internal Medicine/Cardiology

Phone 06131/17-8297
Fax 06131/17-8461
stavros.konstantinides@unimedizin-mainz.de

Lankeit, MD
Mareike Lankeit, MD

Position: Junior group leader

Phone 06131/17-8381
Fax 06131/17-8461
mareike.lankeit@unimedizin-mainz.de

Project management

Geilert
Kristin Geilert

Position: Project coordination "Clinical Trials"

Phone 06131/17-8382
Fax 06131/17-8461
kristin.geilert@unimedizin-mainz.de

Quitzau
Kurt Quitzau

Position: Study coordinator

Phone 06131/17-8252
Fax 06131/17-8461
kurt.quitzau@unimedizin-mainz.de

PhD Heydenreich
Nadine Heydenreich , PhD

Position: Study coordinator

Phone 06131/17-8376
nadine.heydenreich@unimedizin-mainz.de

Wärntges, MD
Simone Wärntges, MD

Position: Research doctor

Phone 06131/17-8251
Fax 06131/17-8461
simone.waerntges@unimedizin-mainz.de

Research

Käberich, MD
Anja Käberich, MD

Position: Research physician

Phone 06131/17-8387
Fax 06131/17-8461
anja.kaeberich@unimedizin-mainz.de

Klok, MD, PhD
Frederikus (Erik) Klok, MD, PhD

Position: Candidate of the Virchow-Fellowship-Program / Research doctor

Phone 06131/17-8380
Fax 06131/17-8461
Frederikus.Klok@unimedizin-mainz.de
Further Information

Nickels, MD
Stefan Nickels, MD

Position: Research physician

Phone 06131/17-8380
stefan.nickels@unimedizin-mainz.de

Rost
Kathrin Rost

Position: Medical technical assistance

Phone 06131/17-8385
Fax 06131/17-8461
kathrin.rost@unimedizin-mainz.de

Schmidt, MD
Kai-Helge Schmidt, MD

Position: Specialist in Internal Medicine
Qualifications: Assistant doctor

kai_helge.schmidt@unimedizin-mainz.de

cand. med. Terporten
Johannes Terporten, cand. med.

Position: PhD student

Statistics

Seeber
Valerie Seeber

Position: Statistician

Phone 06131/17-8384
Fax 06131/17-8461
valerie.seeber@unimedizin-mainz.de

Study nurses

Berghausen
Beate Berghausen

Position: Study Nurse

Phone 06131/17-8386
Fax 06131/17-47 1622
beate.berghausen@unimedizin-mainz.de

Fischer
Brunhilde Fischer

Position: Study Nurse

Phone 06131/17-8386
Fax 06131/17-8461
brunhilde.fischer@unimedizin-mainz.de

References

  • Konstantinides S, Lankeit M. Pulmonary embolism holinw 2012. Recent and expected trials. Hamostaseologie 2013. Feb; 33(1):43-50. doi: 10.5482/HAMO-12-12-0024.

  • Lankeit M, Gómez V, Wagner C, Aujesky D, Recio M, Briongos S, Moores L, Yusen R, Konstantinides S, Jiménez D on behalf of the IRYCIS Pulmonary Embolism Study Group. A strategy combining imaging and laboratory biomarkers in comparison to a simplified clinical score for risk stratification of patients with acute pulmonary embolism. Chest 2012;141:916-922.

  • Lankeit M, Jiménez D, Kostrubiec M, Dellas C, Hasenfuß G, Pruszczyk P, Konstantinides S. Predictive value of the highly sensitive troponin T assay and the simplified Pulmonary Embolism Severity Index in hemodynamically stable patients with acute pulmonary embolism: a prospective validation study. Circulation 2011;124:2716-2724.

  • Konstantinides S, for the PEITHO Steering Committee. Single-bolus tenecteplase plus heparin compared with heparin alone for normotensive patients with acute pulmonary embolism who have evidence of right ventricular dysfunction and myocardial injury: rationale and design of the Pulmonary Embolism Thrombolysis (PEITHO) trial. Am Heart J 2012;163:33-38.e1.

  • Dellas C, Lankeit M, Reiner C, Schäfer K, Hasenfuss G, Konstantinides S. BMI-independent inverse relationship of plasma leptin levels with outcome in patients with acute pulmonary embolism. Int J Obes (Lond) 2013 Feb; 37(2):204-10

  • Vedovati MC, Becattini C, Agnelli G, Kamphuisen PW, Masotti L, Pruszczyk P, Casazza F, Salvi A, Grifoni S, Carugati A, Konstantinides S, Schreuder M, Golebiowski M, Duranti M. Multidetector computed tomography for acute pulmonary embolism: embolic burden and clinical outcome. Chest 2012 May; 142(6):1417-24

  • Konstantinides S, Goldhaber SZ. Pulmonary embolism: risk assessment and management. Eur Heart J 2012; 33(24):3014-22.
NEWS

The new guidelines of the ESC (2.5 MB) for diagnosis and therapy of acute pulmonary embolism (Chair of the Task Force: Stavros Konstantinides) were presented on the ESC in Barcelona.