Juniorgroup "Experimental Research"
Markus Bosmann, MD
Leader Juniorgroup "Experimental Research"
Sepsis and acute lung injury (ALI, ARDS) are life-threatening diseases and frequently require treatment in critical care medicine. The annual incidence of sepsis and ALI is approximately 150,000 cases in Germany. Immunocompromised patients are under increased risk for the development of infections, which can progress to sepsis or/and ALI. Additional complications can arise from severe disturbances in the blood clotting system (e.g. disseminated intravascular coagulopathy) during sepsis and ALI.
Accumulating evidence suggests key roles of the coagulation system and innate immune responses during sepsis and ALI. The release of a plethora of inflammatory mediators (e.g. IL-27, C5a) is observed and accompanied by complex interactions of intracellular signaling cascades and down-stream effects on coagulation. The focus of our research projects is on the molecular interactions of blood coagulation and the innate immune responses. In detail, the roles of plasmatic and cellular components of coagulation are investigated. We study the immune-modulatory functions of platelets and role of coagulation factors in macrophages and type II alveolar epithelial cells. Additional projects are related to coagulation-activating molecules / novel pathogen-associates molecular patterns (e.g. polyphosphates) as well as signal transduction pathways (e.g. MAVS, MDA5, RIG-I) in the context of coagulopathies during sepsis and ALI.
Our studies will contribute to a better understanding of the molecular pathogenesis of sepsis and acute lung injury, thereby helping to identify new avenues for therapeutic interventions.
- Molecular pathogenesis of sepsis and acute lung injury (ALI)
- Interactions of acute inflammation and the coagulation system
- Role of immunologic mediators (e.g. IL-27) during innate immune responses
- Cross-talk of the complement system and coagulation
Partners of Collaboration
- Matthias Theobald, MD (Professor of Medicine, Director of the III. Department of Medicine, Division of Hematology, Oncology, Pulmonology, University Medical Center Mainz)
- Peter A. Ward, MD (Godfrey D. Stobbe Professor, Department of Pathology, University of Michigan, Ann Arbor, USA)
- Professor James H. Morrissey, PhD (Professor of Biochemistry, Molecular and Cellular Biology, Department of Biochemistry) and Stephanie A. Smith, PhD (Assistant Professor, Department of Biochemistry)
- Professor James H. Morrissey, University of Illinois, Urbana, USA
- Heiko Mühl, PhD (Professor of Pharmacology and Toxicology, Center of Pharmacology, Johann Wolfgang Goethe-University, Frankfurt a.M., Germany)
- Peter J. Murray, PhD (Associate Member, St. Jude Faculty, Departments of Infectious Diseases and Immunology, St. Jude Children’s Research Hospital, Memphis, USA)
- CTH/BMBF (Federal Ministry of Education and Research, Modul A, JG)
- DFG (German Research Foundation, BO 3482/3-1)
- MAIFOR Program
- B. Braun Foundation
- Internal university research funding, Level I
- EU Marie Curie Career Integration Grant (CIG)
EHA Clinical Research Fellowship
The team of the Juniorgroup for Experimental Research you will find in building 708, 2nd floor.
Team - Juniorgroup Experimental Research
Bosmann M, Grailer J.J., Ruemmler R, Russkamp N.F., Zetoune F.S., Sarma J.V., Standiford T.J., Ward P.A. Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury. The FASEB Journal. 2013 Aug 27. [Epub ahead of print]
Bosmann M, Ward P. Modulation of inflammation by interleukin-27. Journal of Leukocyte Biology. 2013 July 31. Epub ahead of print - doi:10.1189/jlb.0213107
- Ward P. A., Bosmann M. A historical perspective on sepsis. The American Journal of Pathology. 2012 Jul;181(1):2-7. Epub 2012 May 26.
- Bosmann M., Ward P. A. The inflammatory response in sepsis. Trends Immunology. 2012 Oct 2;1471-4906(12)00162-7.[Epub ahead of print].
- Bosmann M., Ward P. A. Role of C3, C5 and anaphylatoxin receptors in acute lung injury and in sepsis (Review). Adv Exp Med Biol. 2012;946:147-59.
Bosmann M, Meta F, Ruemmler R, Haggadone MD, Sarma JV, Zetoune FS, Ward PA. Regulation of IL-17 Family Members by Adrenal Hormones During Experimental Sepsis in Mice. American Journal of Pathology. 2013 Apr;182(4):1124-30. doi: 10.1016/j.ajpath.2013.01.005.
- Bosmann M., Zhu K., Grailer J. J., Matthay M. A., Sarma J. V., Zetoune F. S., Ward P. A. Anti-inflammatory Effects of ß2 Adrenergic Receptor Agonists in Experimental Acute Lung Injury. FASEB Journal. 2012 May;26(5):2137-44. Epub 2012 Feb 7.
- Bosmann M., Sarma J. V., Atefi G., Zetoune F. S., Ward P. A. Evidence for anti-inflammatory effects of C5a on the innate IL-17A/IL-23 axis. FASEB Journal. 2012 Apr;26(4):1640-51. Epub 2011 Dec 27.
- Bosmann M., Patel V. R., Russkamp N. F., Pache F., Zetoune F. S., Sarma J. V., Ward P. A. MyD88-dependent production of IL-17F is modulated by the anaphylatoxin C5a: Role of the Akt signaling pathway. FASEB Journal. Feb 7. 2011 Dec;25(12):4222-32. Epub 2011 Aug 22.
- Bosmann M., Haggadone M. D., Hemmila M. R., Zetoune F. S., Sarma J. V., Ward P. A. Complement activation product C5a is a selective suppressor of TLR4-induced, but not TLR3-induced, production of IL-27(p28) from macrophages. Journal of Immunology. 2012 May 15;188(10):5086-93. Epub 2012 Apr 9.